SU5416 inhibitors from medchemexpress

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Semaxanib (SU5416) is a potent and selective VEGFR(Flk-1/KDR) inhibitor with IC50 of 1.23 μM, 20-fold more selective for VEGFR than PDGFRβ, lack of activity against EGFR, InsR and FGFR.
SU5416 (Semaxinib), a VEGF receptor inhibitor and an aryl hydrocarbon receptor (AHR) agonist, represents a new alternative for immunomodulation. SU5416 went as far as Phase III clinical trials as an anticancer agent, putatively because of its activity as a VEGFR-2 inhibitor. SU5416 has biologic activity in patients with refractory acute myeloid leukemia or myelodysplastic syndromes. SU5416 inhibits tumor vascularization and growth of multiple tumor types.