SU5416 (Semaxinib), cas NO.204005-46-9,a VEGF receptor inhibitor and an aryl hydrocarbon receptor (AHR) agonist, represents a new alternative for immunomodulation. SU5416 went as far as Phase III clinical trials as an anticancer agent, putatively because of its activity as a VEGFR-2 inhibitor. SU5416 has biologic activity in patients with refractory acute myeloid leukemia or myelodysplastic syndromes. SU5416 inhibits tumor vascularization and growth of multiple tumor types.
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